United In ALS research and care.

Uniting world-leading ALS researchers, clinicians, care providers, and individuals impacted by ALS to accelerate the discovery of treatments, improve access to equipment and resources, while fostering a deeply connected community. Those living with ALS, caregivers, and families are at the heart of what we do.

No one is ever on the ALS journey alone.

Research

Research

A partnership of world-leading ALS researchers focused on a cure

Get Involved

Care

Providing care and essential resources for those who need it most

Fundraising

Fundraising

Critical funding is necessary to further our united research and care

Working together

With the strength of the most caring community, we advance research towards treatments leading to an ultimate cure for ALS while providing equipment and resources to individuals living with the disease now in order to ensure the very best support, access to treatment, and quality of life for them during their journey with the currently 100% terminal disease.

8th Annual ALS Research Symposium!

We are gearing up for our annual ALS Research Symposium, held this year on November 12, 13, and 14th – all three days via Zoom to enable anyone to join from anywhere in the world with ease. CALL FOR ABSTRACTS: IF YOU ARE AN ALS RESEARCHER interested in speaking during our Symposium’s Industry Day (Nov. 13, 2025), about an ALS treatment that you/your company, institute, pharma has in development, we encourage you to email your abstract title and description as well as the speaker’s name by August 31, 2025, to jen@alsone.org for consideration.

Click HERE to Register for free!

FACES OF ALS. We proudly honored your ALS Heroes.

Although for us and all impacted, every month is ALS Awareness Month, we were honored to commemorate the official month (May), by featuring our Faces of ALS gallery on social media for the 10th year in a row. Tributes were submission-based and it was our honor to include anyone and everyone who wanted to be included.

View all submissions HERE to read about all these incredible individuals.

Respiratory Strength Training in ALS.

Review 5: “Respiratory Strength Training in ALS”: Air Date: June 10, 2025 • 4pm EDT

Join us for an insightful webinar as we explore the publication titled “Respiratory Strength Training in ALS,” which highlights over a decade of groundbreaking research on this critical topic. Find out what it is, if you are unfamiliar, and how it might be of help. We’re honored to welcome two of the publication’s esteemed authors: Dr. Emily Plowman, PhD and Dr. James Wymer, MD; along with panelists, Dr. Bill Su, Gwen Petersen and Steve Kowalski, both inspiringly living with ALS for over seven years and serving as NEALS ALS Research Ambassadors and passionate advocates within the ALS community; and Jennifer DiMartino, our Executive Director here at ALS ONE.
🖥️ Watch the recording HERE.
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Read the publication ahead of time, at: https://pubmed.ncbi.nlm.nih.gov/36805435/



Upcoming Events

ROCK OUT ALS
June 28, 2025
ROCK OUT ALS
Join us to Rock out ALS with the live music of Beware of Dogs at Players Sports Bar & Grille in Rockland! Presented by Rise Against ALS to fully fund our research and care! Tickets are $20 online and $25 at the door.
9th Annual Golf Tourney - Luau on the Links!
July 14, 2025
9th Annual Golf Tourney - Luau on the Links!
Sponsorships and Foursomes now on sale! Join us at Granite Links for our 9th annual Golf Tourney - Luau on the Links! Scramble start time is 1:30 with reception following. Get your Hawaiian shirts ready, it'll be ONE great day!
2025 FALMOUTH ROAD RACE TEAM
August 17, 2025
2025 FALMOUTH ROAD RACE TEAM
Join our AMAZING Falmouth Road Race Team and support ALS research AND care! Our team, our "FALMily" means the WORLD to us and every year, our team gets bigger and better than ever, making a HUGE impact and making the world of ALS a lot brighter! Race day is Sunday, August 17th and whether you join us in person in beautiful Falmouth MA for the most scenic run, or from afar, we'll have so much fun as we run to make ALS DONE!

December 2024, Whitman, MA. ALS ONE, with the help of ALS Finding a Cure (ALSFAC), builds upon a unique program to better connect, support, and serve the ALS community.

Massachusetts-based ALS ONE, a recognized leader in ALS research, care, and community, is proud to announce that they have been selected as a 2024 winner of the ALSFAC WE CARE Grant to expand upon their Pals for pALS Community Connect Program. This unique and deeply personal program is designed to foster meaningful connections between individuals and families currently living with ALS and those who have previously navigated the journey and now wish to give back.

Rooted in empathy and experience, Pals for pALS builds a bridge between past and present — empowering those who have lost loved ones to ALS to become an invaluable source of guidance, strength, and hope for newly diagnosed families. While these types of connections have occurred informally within the ALS community for years, the $75,000 in funding from ALSFAC will help to create structure, enable ALS-impacted individuals and families to have welcomed outings to connect, and provide resources needed to make this program’s pivotal relationships consistent, supportive, and impactful.

The program offers flexible pathways for involvement, recognizing that everyone’s capacity and comfort level for engagement is different. Whether offering a listening ear, sharing practical tips, helping with chores, or simply providing emotional solidarity, every connection matters — and every story has the power to heal.

ALS ONE is honored to receive this tremendous funding from ALS Finding a Cure, whose WE CARE Grant has made it possible to expand and sustain the program in its first year. This critical support allows ALS ONE to offer the Pals for pALS Community Connect Program at no cost to participants, helping to expand and strengthen the ALS support network in unprecedented ways.

“This program represents the heart of who we are — uniting science and compassion, past and present, in the name of care, connection, and ultimately, a cure. We are extremely grateful to ALS Finding a Cure for their immense generosity in helping to turn our vision into a structured, dynamic new program. Being selected for the 2024 ALSFAC WE-CARE Grant means the world to us.  We here so often from those who have lost loved ones or friends to ALS that they would love nothing more than to help others navigate the devastating complexities and this program will provide the structure, guidance, and funding to do just that.  We know our founder, Kevin Gosnell, and all other ALS angels with him are surely smiling down on the impact that this program will have.”, stated ALS ONE’s Executive Director, Jennifer DiMartino.

Read the full press release about the Pals for pALS initiative HERE

November 2024, Boston MA

The initiative will be led by a team of clinical investigators from both Mass General and Northwestern. The Mass General team will be comprised of Merit Cudkowicz, M.D., MS.C., Sabrina Paganoni, M.D., Ph.D., and Doreen Ho, M.D. Senda Ajroud-Driss, M.D., will lead the team at Northwestern. Between the two centers, the ACE initiative will provide funding for staff, training, and infrastructure to accelerate participation in research, ultimately broadening access to potential treatments and programs for people living with ALS.

Announcing a powerful new initiative to advance ALS research, of which we are a proud support partner! Together with the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital and the Les Turner ALS Center at Northwestern Medicine, we are thrilled to announce the launch of the Acceleration Centers of Enrollment (ACE) initiative: The ACE initiative aims to accelerate enrollment and operational improvements in ALS clinical research by increasing access to clinical trials, expanded access protocols, and non-therapeutic research studies. Support for the ACE initiative comes from an Anonymous donor, ALS ONE, and the Les Turner ALS Foundation.

“We need transformative initiatives to change the trajectory of ALS research and care,” said Dr. Paganoni. “With programs like ACE coming to fruition, we are forging new paths for those who desire to contribute to research and gain access to clinical trials, expanded access and other important studies.”

The HEALEY ALS Platform Trial has been a leader in pioneering innovation and advancing research in ALS. There is tremendous interest in participating in this study as well as other exciting research projects. The ACE initiative will improve access and efficiency, funding training and salaries of additional staff, and ultimately broadening access for people with ALS to potential treatments and programs.

“ALS ONE is honored to be a support partner of the Acceleration Centers of Enrollment (ACE) initiative. This innovative program will significantly enhance access to critical clinical trials and research studies for people living with ALS” said Jennifer DiMartino, Executive Director of ALS ONE. “ACE is a vital step towards faster, more efficient research and ultimately, finding treatments and a cure for ALS.”

Read the full press release about The ACE initiative HERE.

December 2024, Clearwater, FLA- The Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH) awarded the annual 2023 Gupta Family Endowed Prize for Innovation in ALS Care to both ALS ONE and Compassionate   ALS (CCALS). The prize was presented to the teams during the 22nd Annual Northeast ALS Consortium (NEALS) Meeting in Clearwater Beach, FL by Dr. Merit Cudkowicz, Director of the Healey & AMG Center for the Gupta family.

The selection committee agreed ALS ONE and CCALS are the most deserving recipients of the 2023 award for their joint efforts in innovation and dedication to improving lives of people with amyotrophic lateral sclerosis (ALS) in their homes. ALS ONE and CCALS also demonstrate excellence in their partnership and serve as a model for how foundations can work together to make a significant impact.

ALS ONE consists of world-renowned clinicians and researchers who work to expedite treatments and ultimately find a cure for ALS while improving the care now for those living with the disease. ALS ONE links innovative researchers, medical providers, and care resources to drive key studies forward and initiate efforts, such as transportation studies, that fall outside of medicine. The critical data that is collected by ALS ONE is pivotal in the innovation of treatments for people with ALS (PALS).

Jennifer DiMartino, ALS ONE’s Executive Director was overjoyed to receive this news.  “We are profoundly honored to be one of the two recipients of the 2023 Gupta Family Endowed Prized for Innovation in ALS care.  ALS ONE was established in 2016 with the primary objective of bringing together ALS researchers, clinicians, and care providers to not only streamline the advancement of critical ALS research but to also work collaboratively to enhance the quality of life for individuals currently battling this disease and we are so humbled and proud of the work we do to help ALS families” she said.  “By working together, we ensure that ALS families receive the essential equipment and resources needed to navigate the complexities of the disease and this award means the world to us.  We are deeply grateful to receive this prize alongside CCALS, an organization with which we collaborate daily towards our shared objective and are certain that our founder, Kevin Gosnell, who tragically lost his life to ALS in 2016, would feel immeasurable pride in witnessing our unwavering dedication to expanding access to care and enhancing the quality of life for everyone affected by that relentless disease.”

Originally founded in 1998 Compassionate Care ALS (CCALS) is a nonprofit organization with a mission to support people diagnosed with ALS, their families, healthcare providers, and communities as they navigate the physical and emotional complexities associated with the disease. The organization provides a myriad of resources including; equipment, educational opportunities, insurance and Medicare assistance, guidance and awareness with regards to living with ALS, caregiving, and exploring end-of-life when invited. CCALS offers an innovative approach to delivering support and services to our clients, tailored to the needs of each individual and their support network. 

Ron Hoffman, Founder/Executive Director of CCALS is thrilled to receive this award. “The impact of receiving the Gupta Family Endowed Prize is a significant honor. To be recognized for our innovative approach to patient care along with our good friends at ALS One demonstrates the power of the impact our organization has on ALS families. The Sean M Healey & AMG Center for ALS at MGH selection of our organization emphasizes the importance of care for ALS patients and the fact that CCALS is able to improve the quality of life for each one of the more than 1,050 families we serve,” he says.

“The work of both ALS ONE and CCALS are nothing short of pivotal to the ALS community, and met the review criteria of being accessible, scalable and important for care,” said Merit Cudkowicz, MD, MSc, Director of the Healey & AMG Center and Chief of Department of Neurology at MGH. “We are grateful to the Gupta Family for making this prize possible to recognize idea sharing, innovation, and forward thinking on scalable ongoing and ground-breaking foundations like ALS ONE and CCALS that have directly improved ALS patient care.” The Gupta Family Endowed Prize for Innovation in ALS Care is a global prize to honor ground-breaking new approaches that lead to exceptional care for individuals living with ALS. This annual prize is awarded to a nominated team who has developed promising new approaches to improving care for people living with ALS. The goal of this prize is to encourage idea sharing, innovation, and forward thinking on scalable ongoing and ground-breaking projects that have directly improved ALS patient care.

Read the full press release on the Gupta Family Endowed Prize for Innovation in ALS Care HERE.